Many modern analog-to-digital converters (ADCs) use differential inputs to reject common-mode noise and interference, increase dynamic range, and improve the overall performance. Although ADCs with differential inputs can accept single-ended input signals, optimum ADC performance is reached when the input signal is differential. As a result, differential ADC drivers have become essential signal conditioning elements in data acquisitioning systems. This application note presents many different design considerations for differential ADC drivers such as the input common-mode voltage range, input and output coupling, output swing, and harmonic distortion.