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Shire rejects 43bn offer from Japan's Takeda Pharmaceutical

Takeda says it is in talks with Shire about a potential bid for the London-listed drug maker.

Japan's ambassador warns that no company could stay in the UK if it was not making a profit.

Major Japanese investors in Britain, including carmakers,, are due to meet the prime minister and chancellor.

The index was helped by gains on Wall Street during a holiday in Japan on Monday.

Growth was driven by rising exports and increased investment by Japanese companies.

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