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Making The Most of Biomarkers In Preclinical Studies
2015-03-09 12:05:46| drugdiscoveryonline Home Page
By Adam Aulbach, DVM, DACVP, MPI Research Biomarkers are a useful tool in clinical trials, especially in identifying a drug’s impact on organs or tissues before any injury is clinically evident. It’s still early in their use in preclinical development; however, they are proving helpful in identifying major safety issues and showing promise for future use. Presently, biomarkers are used with clinical and pathology endpoints to identify the effects of a preclinical drug candidate far earlier than do traditional tests alone. But sometimes those biomarkers can lead to conflicting data. The assays may be so sensitive that they show evidence of toxicity—often a submicroscopic effect—that doesn’t appear in conventional study endpoints. How to explain those results, and whether they are relevant, presents a challenge best addressed by consulting with a pathologist before designing a study. Understanding the timing of pathologic processes is critical to interpreting results.
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biomarkers
Making financial decisions when you lose your job
2015-03-07 05:43:59| Beverages - Topix.net
Those figures represent little more than 1 percent of the workforce, but they still underscore just how many people face the sort of upheaval that accompanies the loss of a job or a forced retirement. Beyond the emotional toll, many agonize over potentially life-altering financial decisions, including how best to manage any money they may be going out the door with.
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job
financial
Making night vision, thermal imaging affordable
2015-03-05 14:21:44| Electronics - Topix.net
Researchers have created an electronic device using CMOS technology that detects electromagnetic waves to create images at nearly 10 terahertz, which is the highest frequency for electronic devices. The device could make night vision and heat-based imaging affordable.
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night
vision
affordable
Making night vision, thermal imaging affordable
2015-03-05 09:22:00| Semiconductors - Topix.net
Researchers have created an electronic device using CMOS technology that detects electromagnetic waves to create images at nearly 10 terahertz, which is the highest frequency for electronic devices. The device could make night vision and heat-based imaging affordable.
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night
vision
affordable
The growing anti-science movement is making people in Silicon Valley nervous
2015-03-02 10:25:00| Climate Ark Climate Change & Global Warming Newsfeed
business Insider: I was at a small dinner party Saturday night, and a big part of the conversation revolved around an article in this month's National Geographic about how many Americans doubt science. For instance, scientists now accept that the earth's atmosphere is getting warmer because people are pumping carbon dioxide into the air and that this will cause dramatic changes in the climate. But only 40% of Americans believe this is true, according to a recent poll by Pew Research Center. Another example:...
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valley
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