Suitable for screening and exploratory studies, Sigma CRISPRs are packaged in single plasmid vector containing GFP for enrichment of gene-edited cells, and can be custom-designed online using bioinformatics tool. Derived from bacterial and archaeal immune defenses, which guard against invading viruses and foreign DNA, Sigma CRISPRs utilize customizable RNA-nuclease complexes that allow introduction of genome edits at desired site in mammalian genomes with high efficiency.
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