Developed by introducing adamantyl groups as functional group of reversed stationary phase of HPLC column, Shiseido Capcell Pak ADME Columns provide ADME separation characteristics with balance between moderate hydrophobicity and extra-high surface polarity. HPLC particle technology uses polymer coated 2.7 µm particle with 1.7 µm core and a 0.5 µm porous outer layer. Polymer coating eliminates effects of unprotected silanol groups on packing material.