In D'Arcy v Myriad Genetics Inc [2015] HCA 35 the High Court of Australia has unanimously held and two concurring decisions that claims to isolated nucleic acids coding for mutations or polymorphisms of the BRCA1 gene, do not meet the requirements of a 'manner of manufacture' within the meaning of the Patents Act 1990 and are therefore not a patentable invention in Australia. The High Court's decision overturned Justice Nicholas' decision at first instance, and a unanimous decision of an expanded bench of five judges of the Full Federal Court of Australia.