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Optimization Of Design Space And Throughput Conditions For Scale Up Of A Low- Dose Roller Compacted Product

2015-01-20 11:23:07| drugdiscoveryonline Downloads

Roller compaction of low dose active pharmaceutical ingredients into solid dosages forms is quite challenging.  Ribbon porosity, tensile strength, mean granule size and surface area are key quality attributes that can affect downstream processing and final product performance. These parameters were evaluated in the present study to establish a design space and operational conditions for roller compaction of a placebo tablet blend that closely mimics the formulation requirements of low dose pharmaceutical active ingredients. This study also helps to minimize the API need that often in limited supply during early stage of drug development.

Tags: conditions design product low

Category:Biotechnology and Pharmaceuticals

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