Home The Role Of Swine As Preclinical Models For Cardiovascular Disease
 

Keywords :   


The Role Of Swine As Preclinical Models For Cardiovascular Disease

2015-03-09 11:59:54| drugdiscoveryonline Home Page

By Mark Johnson, M.S. Senior Director of Surgery Classically, pharma, biotech, and device researchers have relied on rodent models to discover and validate disease targets and mechanisms, as well as for the preclinical development of therapeutics. However, the biology of rodents often fails to accurately predict outcomes in patients – perhaps not surprisingly, as mice are not simply miniature people, but have differences in immune function, lifespan, hematological function, regenerative capacity, and environment (sterile and controlled versus complex and dirty). This lack of translational validity has contributed, in part, to the high failure rate for drug development, particularly in the expensive clinical stage. The use of models in larger animals can help address some of these differences between rodents and human, particularly in cardiovascular disease.

Tags: role models disease cardiovascular

Category:Biotechnology and Pharmaceuticals

Latest from this category

All news

»
06.11Eastern North Pacific Tropical Weather Outlook
05.11Tropical Storm Rafael Graphics
05.11Tropical Storm Rafael Forecast Discussion Number 9
05.11Tropical Storm Rafael Wind Speed Probabilities Number 9
05.11Tropical Storm Rafael Public Advisory Number 9
05.11Summary for Tropical Storm Rafael (AT3/AL182024)
05.11Tropical Storm Rafael Forecast Advisory Number 9
05.11Delayed implementation of EID eartag rule requested
More »