Utilizing automatic extraction and chromatographic separation combined with high-sensitivity detection of targets by mass spectrometry, Nexera UC can sequentially analyze up to 48 samples. Supercritical fluidic chromatography-based system eliminates need for sample pre-treatment and enables stable analysis of delicate samples that are prone to oxidation or dissociation if exposed to air. By injecting entire volume of eluent, Nexera UC achieves high levels of sensitivity.