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British Medical Journal study into paroxetine, Aropax, reveals suicide risk

2015-09-17 03:38:24| Biotech - Topix.net

An ineffective depression drug was prescribed in the millions to children on the basis of flawed research that downplayed its risks of suicide and other serious events and overstated its benefits, a groundbreaking study has shown. An international team of researchers has obtained previously buried data from a now infamous trial of the antidepressant medication paroxetine, which is sold under the brand names Aropax here and Paxil overseas.

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The Wall Street Journal: Shire weighs options to sweeten all-stock offer for Baxalta

2015-09-14 09:09:43| Biotech - Topix.net

Shire PLC is weighing options for sweetening its multibillion-dollar, all-stock offer for U.S. biotechnology firm Baxalta Inc. by putting cash into shareholders' hands sooner, said people familiar with the matter. disclosed last month and valued at $30.6 billion based on Shire's stock price at the time-excluded any cash.

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New England Journal of Medicine (NEJM) Publishes Pivotal Phase 3 Data...

2015-09-10 06:45:57| Biotech - Topix.net

Alexion Pharmaceuticals, Inc. announced today that data from the pivotal Phase 3 ARISE study evaluating the safety and efficacy of Kanumaa in children and adults with lysosomal acid lipase deficiency have been published in the September 10 issue of the New England Journal of Medicine . In the study, Kanuma met the primary endpoint of alanine aminotransferase normalization compared with placebo as well as six secondary endpoints.1 Kanuma is an innovative enzyme replacement therapy that has been approved by the European Commission for the treatment of patients of all ages with LAL-D, a genetic, chronic, and progressive ultra-rare metabolic disease in which infants, children and adults suffer multi-organ damage and premature death.

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The Wall Street Journal: U.K. clothing retailer Primark makes U.S. debut

2015-09-09 04:28:06| Apparel - Topix.net

British fast-fashion retailer Primark is ready to take on the world's largest clothing market, bringing across the Atlantic its strategy of selling huge volumes of garments sometimes costing less than a sandwich. On Thursday, it will open its first U.S. store in Boston, on the former site of Filene's Basement in Downtown Crossing.

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The Wall Street Journal: Tempur Sealy names auto-industry executive Scott Thompson new CEO

2015-09-08 20:08:52| Auto Dealers - Topix.net

Tempur Sealy International Inc., recently under pressure from an activist investor, on Tuesday named auto-industry executive Scott L. Thompson as its chairman and chief executive officer. Thompson served as Dollar Thrifty Automotive Group Inc.'s CEO and chairman until the company was bought by Hertz Global Holdings Inc. in 2012.

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